Professional and Social Background
Kevin Burrage was a Federation Fellow of the Australian Research Council (2003-2008). Until the end of
2007 he was also Professor of Computational Mathematics at the University of Queensland and Director of
the Advanced Computational Modelling Centre. He was also founding CEO of the Queensland Parallel
Supercomputing foundation (now QCIF).
He is married to Pamela and they have two children: Matthew and Lauren, who are both at the University of
Queensland doing the Medical program.
Kevin joined Oxford University in early 2008 and is Professor of Computational Systems Biology at the
Computing Laboratory and the Oxford Centre for Integrative Systems Biology. He is also professorial
research fellow at the Institute for Molecular Bioscience at the University of Queensland He shares his time
between both institutions. Kevin is also a supernumerary fellow of New College at Oxford University.
Contact Details
Academic Interests
I have general interests in
- Computational Mathematics
- Computational and Systems Biology
- Stochastic modelling for the Life Sciences
- Multiscale modelling and simulation
Links to research partners at the University of Queensland
Computational and Systems Biology
Within Systems Biology, I work on
- Monte Carlo modelling of chemical kinetics on the plasma membrane;
- Genetic regulatory models incorporating noise and delays with applications to tHes 1 and Her 1/7;
- Spatial cellular models and particularly granular transport of insulin in the pancreatic Beta cell;
- Multiscale models incorporating noise at many different temporal and spatial scales;
- Construction and analysis of interaction networks;
- The role of small numbers of protein in immunological applications.
Selected Publications
Here is some recent work that I have done in Systems Biology: Reprints can be got from me via email.
- S.MacNamara , K. Burrage and R. B. Sidje (2008): Multiscale modeling of chemical kinetics via the
master equation, to appear in SIAM J. Multiscale Modelling and Simulation Multiscale Modeling &
Simulation (Vol.6, No.4).
- K. Burrage, I. Lenane and G. Lythe (2008): Numerical methods for second order stochastic equations,
SIAM Journal of Scientific Computing, 29, 1, 245-264.
- T. Marquez-Lago, K. Burrage (2007): Binomial tau-leap spatial stochastic simulation algorithm for
applications in chemical kinetics, J. Chem. Phys, 127, 1.
- J. Song, K. Burrage (2007): Predicting disulfide connectivity from protein sequence using multiple
sequence feature vectors and secondary structure, Bioinformatics.
- K. Burrage, J. Hancock, A. Leier, D. V. Nicolau, Jr. (2007): Modelling and simulation techniques for
Membrane Biology, Briefings in Bioinformatics, 8(4): 234-244, July 2007.
- D. V. Nicolau Jr., J. F. Hancock, and K. Burrage (2007): Sources of Anomalous Diffusion on Cell
Membranes: A Monte Carlo Study, Biophysics Journal 92:1975-1987.
- F. Liu, P. Zhuang, V. Anh, I. Turner and K. Burrage (2007): Stability and Convergence of an Implicit
Method for the Space-Time Fractional Advection-Diffusion Equation, Journal of Applied Mathematics and
Computation.
- C-M. Chen, F. Liu and K. Burrage (2007): Finite difference method and a new Fourier analysis for the
Fractional Reaction-Diffusion Equation, Journal of Applied Mathematics and Computation.
- D. Nicolau Jr, K. Burrage, R. G. Parton and J. Hancock (2006): Optimal microdomain characteristics
for nano-scale protein-protein interactions, Molecular and Cellular Biology, January 2006, Vol. 26, No. 1,
p. 313-323.
- T. Tian and K.Burrage (2006): Stochastic models for regulatory networks of the genetic toggle switch,
PNAS, Vol. 103, No. 22, 8372-8377.
- M. Barrio, K. Burrage, A. Leier and T. Tian (2006): Oscillatory Regulation of Hes1: Discrete
Stochastic Delay Modelling and Simulation, PLOS Computational Biology, September 2006, Volume 2,
Issue 9.
- T. Tian, S. Xu, J. Gao and Kevin Burrage (2006): Simulated maximum likelihood method for estimating
kinetic rates in gene expression, Bioinformatics, 2006; doi: 10.1093/bioinformatics/btl552.
- K. Burrage, L. Hood and M. A. Ragan (2006): Advanced computing for systems biology, Briefings in
Bioinformatics, 7: 390-398.
- J. Song, K. Burrage, Z. Yuan and T. Huber (2006), Prediction of cis/trans isomerization in proteins
using psi-BLAST profiles and secondary structure information, BMC Bioinformatics, March 9, 7:124.
- J. Song, M. Wang and K. Burrage (2006): Exploring synonymous codon usage preferences of
disulfide-bonded and non-disulfide bonded cysteines in the E. coli Genome, J Theor Biol., Jan 18, 2006.
- J. Song, and K. Burrage (2006): Predicting residue-wise contact orders in proteins by support vector
regression, BMC Bioinformatics, 7:425, doi:10.1186/1471-2105-7-425.
- T. Tian, K.Burrage, P. M. Burrage and M. Carletti (2006): Stochastic Delay Differential Equations for
Genetic Regulatory Networks, Special Issue of J. Comp and Applied Maths,
doi:10.1016/j.cam.2006.02.063 .
- K. Burrage, P. Burrage, D. J. Higham, P. E. Kloeden, E.Platen (2006): Comments on Numerical
methods for stochastic differential equations: a correction and a warning, Physical Review E, 74, 068701.
- T. Tian and K. Burrage (2004): Bistability and switching in the lysis lsogeny genetic regulatory network
of Bacteriophage lambda, Journal of Theoretical Biology, 227, 229-237.
- M. Carletti, K. Burrage and P.M. Burrage (2004): Numerical simulation of stochastic ordinary
differential equations in biomathematical modeling, Mathematics and Computers in Simulation, 64, 271-277.
- K. Burrage and T. Tian (2004): Poisson Runge-Kutta methods for Chemical Reaction Systems, in
Advances in Scientific Computing and Applications, Y.Lu W. Sun and T. Tang eds, Science Press,
Beijing/New York, 82-96.
- K. Burrage, T. Tian and P. Burrage (2004): A multi-scaled approach for Chemical Reaction Systems
Modelling Cellular and Tissue Function in Prog. Biophys. Mol. Biol, Vol. 85, Issue 2-3, 217-234.
- N. Hamilton, K. Burrage, M. Ragan and T. Huber (2004): Protein contact prediction using patterns of
correlation, Proteins: Structure, Function and Bioinformatics, 56, 679-684.
- T. E. Turner, S. Schnell and K. Burrage (2004): Stochastic modelling of intracellular reactions,
Computational Biology and Chemistry, 28, 3, 165-178.
- T. Tian and K. Burrage (2004): Binomial leap methods for simulating stochastic chemical kinetics,
J.Chem. Phys., 121, 10356-10364.
- L.Croft, S. Schandoff, F. Clark, K. Burrage, P. Actander and J.S. Mattick (2000): ISIS the intron
information system reveals the frequency of alternative splicing in the human genome, Nature Genetics,
24(4), 340-1.
